Drug interactions
Dosulepin + Risperidone
Severity: Moderate
Dosulepin and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation and orthostatic hypotension, so combined use can increase drowsiness and fall risk. Dosulepin is a tricyclic that can prolong the QT interval, and risperidone may add to this effect.
What this interaction means in plain words
Dosulepin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression, alpha-1 blockade and QT prolongation, with possible CYP2D6 inhibition by antidepressants raising risperidone levels.
What to do
Start with low doses and monitor sedation, blood pressure and ECG in patients with cardiac risk. Counsel on fall risk and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Risperidone?
MediHelp rates the interaction as moderate. Dosulepin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation and orthostatic hypotension, so combined use can increase drowsiness and fall risk. Dosulepin is a tricyclic that can prolong the QT interval, and risperidone may add to this effect.
How serious is the interaction between Dosulepin and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor sedation, blood pressure and ECG in patients with cardiac risk. Counsel on fall risk and avoid alcohol.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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