Drug interactions
Dosulepin + Rizatriptan
Severity: Moderate
Dosulepin and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic activity, so using them together carries a theoretical risk of serotonin syndrome, with agitation, tremor, sweating, hyperreflexia and hyperthermia. Reported cases with triptans and tricyclic antidepressants are rare, and the risk is considered low.
What this interaction means in plain words
Dosulepin and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from 5-HT1B/1D agonism combined with inhibition of serotonin reuptake by the tricyclic.
What to do
Counsel the patient to report agitation, tremor, sweating or fever promptly, and monitor for serotonin toxicity after starting or increasing either drug. Stop one agent if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Rizatriptan?
MediHelp rates the interaction as moderate. Dosulepin and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic activity, so using them together carries a theoretical risk of serotonin syndrome, with agitation, tremor, sweating, hyperreflexia and hyperthermia. Reported cases with triptans and tricyclic antidepressants are rare, and the risk is considered low.
How serious is the interaction between Dosulepin and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating or fever promptly, and monitor for serotonin toxicity after starting or increasing either drug. Stop one agent if symptoms appear.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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