Drug interactions
Dosulepin + Sevoflurane
Severity: Moderate
Dosulepin and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant that may add to sevoflurane CNS depression. Tricyclics may also contribute to arrhythmias and hypotension under general anesthesia.
What this interaction means in plain words
Dosulepin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression plus tricyclic anticholinergic, alpha-blocking and cardiac conduction effects that may combine with volatile anesthetic cardiovascular effects.
What to do
Inform the anesthesia team of tricyclic use and monitor ECG and blood pressure intraoperatively. Titrate anesthetic carefully and watch for delayed emergence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dosulepin and Sevoflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sevoflurane
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Sevoflurane?
MediHelp rates the interaction as moderate. Dosulepin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant that may add to sevoflurane CNS depression. Tricyclics may also contribute to arrhythmias and hypotension under general anesthesia.
How serious is the interaction between Dosulepin and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of tricyclic use and monitor ECG and blood pressure intraoperatively. Titrate anesthetic carefully and watch for delayed emergence.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
