Drug interactions
Dosulepin + Tiotropium-olodaterol
Severity: Moderate
Dosulepin and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with significant anticholinergic activity, which adds to the effect of inhaled tiotropium. This may cause dry mouth, constipation, urinary retention, blurred vision or raised intraocular pressure. Tricyclics may also potentiate cardiovascular effects of beta2 agonists.
What this interaction means in plain words
Dosulepin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects, with possible added QT and adrenergic cardiovascular effects.
What to do
Monitor for anticholinergic adverse effects such as urinary retention and glaucoma symptoms, especially in older adults. Consider an ECG if other QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Dosulepin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with significant anticholinergic activity, which adds to the effect of inhaled tiotropium. This may cause dry mouth, constipation, urinary retention, blurred vision or raised intraocular pressure. Tricyclics may also potentiate cardiovascular effects of beta2 agonists.
How serious is the interaction between Dosulepin and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects such as urinary retention and glaucoma symptoms, especially in older adults. Consider an ECG if other QT risk factors exist.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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