Drug interactions
Doxapram + Midodrine
Severity: Moderate
Doxapram and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise blood pressure, and doxapram has pressor effects through sympathetic stimulation. Together they may cause excessive hypertension.
What this interaction means in plain words
Doxapram and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxapram belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Additive pressor effects through pharmacodynamic synergism.
What to do
Monitor blood pressure closely during doxapram administration and adjust or hold midodrine if hypertension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Other interactions of Doxapram
- Desflurane + Doxapram Major
- Dextroamphetamine + Doxapram Major
- Doxapram + Isocarboxazid Major
- Doxapram + Ketamine Major
- Doxapram + Linezolid Major
- Doxapram + Lisdexamfetamine Major
Frequently asked questions
Can I take Doxapram with Midodrine?
MediHelp rates the interaction as moderate. Doxapram and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs raise blood pressure, and doxapram has pressor effects through sympathetic stimulation. Together they may cause excessive hypertension.
How serious is the interaction between Doxapram and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during doxapram administration and adjust or hold midodrine if hypertension occurs.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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