Drug interactions
Doxepin + Dronedarone
Severity: Major
Doxepin and Dronedarone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin can prolong the QT interval, mainly at higher doses, and combining it with dronedarone adds to arrhythmia risk. Low-dose doxepin for insomnia carries less risk.
What this interaction means in plain words
Doxepin and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxepin belongs to Dermatology; Dronedarone belongs to Cardiovascular.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Avoid or use the lowest doxepin dose with an ECG and electrolyte monitoring. Consider an alternative with less QT effect.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Dronedarone?
MediHelp rates the interaction as major. Doxepin and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Doxepin can prolong the QT interval, mainly at higher doses, and combining it with dronedarone adds to arrhythmia risk. Low-dose doxepin for insomnia carries less risk.
How serious is the interaction between Doxepin and Dronedarone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or use the lowest doxepin dose with an ECG and electrolyte monitoring. Consider an alternative with less QT effect.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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