Drug interactions
Doxepin + Ethinyl estradiol-drospirenone
Severity: Minor
Doxepin and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing contraceptives may reduce the metabolism of tricyclic antidepressants such as doxepin, potentially raising their concentrations. This could increase anticholinergic, sedative and cardiovascular adverse effects.
What this interaction means in plain words
Doxepin and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Ethinyl estradiol may inhibit oxidative metabolism of tricyclic antidepressants; the mechanism is not fully established.
What to do
Monitor for sedation, anticholinergic effects and orthostasis, and reduce the doxepin dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Doxepin and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogen-containing contraceptives may reduce the metabolism of tricyclic antidepressants such as doxepin, potentially raising their concentrations. This could increase anticholinergic, sedative and cardiovascular adverse effects.
How serious is the interaction between Doxepin and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, anticholinergic effects and orthostasis, and reduce the doxepin dose if adverse effects emerge.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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