Drug interactions
Doxepin + Gemifloxacin
Severity: Moderate
Doxepin and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemifloxacin and doxepin can each prolong the QT interval, so together they may raise the risk of torsades de pointes. Higher doxepin doses and electrolyte disturbances increase the concern.
What this interaction means in plain words
Doxepin and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Check baseline ECG and correct potassium and magnesium. Keep doxepin at the lowest effective dose and consider an alternative antibiotic in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Gemifloxacin?
MediHelp rates the interaction as moderate. Doxepin and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemifloxacin and doxepin can each prolong the QT interval, so together they may raise the risk of torsades de pointes. Higher doxepin doses and electrolyte disturbances increase the concern.
How serious is the interaction between Doxepin and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium. Keep doxepin at the lowest effective dose and consider an alternative antibiotic in patients with other risk factors.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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