Drug interactions
Doxepin + Indacaterol-glycopyrronium
Severity: Moderate
Doxepin and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a tricyclic antidepressant with anticholinergic activity and QT-prolonging potential. It may add to glycopyrronium antimuscarinic effects, and tricyclics can potentiate cardiovascular effects of beta2-agonists like indacaterol.
What this interaction means in plain words
Doxepin and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects, additive QT prolongation, and potentiation of beta2-agonist cardiovascular effects.
What to do
Monitor ECG and heart rate in patients with cardiac risk factors. Watch for urinary retention, constipation and confusion, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Doxepin and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a tricyclic antidepressant with anticholinergic activity and QT-prolonging potential. It may add to glycopyrronium antimuscarinic effects, and tricyclics can potentiate cardiovascular effects of beta2-agonists like indacaterol.
How serious is the interaction between Doxepin and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate in patients with cardiac risk factors. Watch for urinary retention, constipation and confusion, especially in older patients.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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