Drug interactions
Doxepin + Lurasidone
Severity: Moderate
Doxepin and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lower blood pressure, causing orthostatic hypotension, and both can cause sedation. Together these effects may be additive, with a higher risk of dizziness and falls. Doxepin also has anticholinergic activity.
What this interaction means in plain words
Doxepin and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Lurasidone belongs to Central Nervous System.
Why it happens
Additive alpha-1 adrenergic blockade and CNS depressant effects (pharmacodynamic).
What to do
Monitor blood pressure, including orthostatic readings, and sedation, particularly at initiation or after dose increases. Rise slowly and reduce the dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Lurasidone?
MediHelp rates the interaction as moderate. Doxepin and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can lower blood pressure, causing orthostatic hypotension, and both can cause sedation. Together these effects may be additive, with a higher risk of dizziness and falls. Doxepin also has anticholinergic activity.
How serious is the interaction between Doxepin and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including orthostatic readings, and sedation, particularly at initiation or after dose increases. Rise slowly and reduce the dose if symptomatic.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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