Drug interactions
Doxepin + Mefloquine
Severity: Moderate
Doxepin and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin, a tricyclic antidepressant, can prolong the QT interval, particularly at higher doses or in overdose. Together with mefloquine this may increase the risk of ventricular arrhythmias. Both drugs also affect the CNS, so neuropsychiatric effects may be compounded.
What this interaction means in plain words
Doxepin and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization (QT prolongation).
What to do
Prefer an alternative antimalarial where feasible. If both are required, check a baseline ECG, correct electrolytes, and monitor for palpitations, syncope and psychiatric symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Mefloquine?
MediHelp rates the interaction as moderate. Doxepin and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin, a tricyclic antidepressant, can prolong the QT interval, particularly at higher doses or in overdose. Together with mefloquine this may increase the risk of ventricular arrhythmias. Both drugs also affect the CNS, so neuropsychiatric effects may be compounded.
How serious is the interaction between Doxepin and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antimalarial where feasible. If both are required, check a baseline ECG, correct electrolytes, and monitor for palpitations, syncope and psychiatric symptoms.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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