Drug interactions
Doxepin + Peginterferon alfa 2b
Severity: Minor
Doxepin and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa-2b may modestly alter CYP2D6 activity, potentially changing doxepin exposure. Interferons also commonly cause depression and insomnia, so doxepin response should be followed.
What this interaction means in plain words
Doxepin and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Possible modulation of CYP2D6 metabolism by interferon.
What to do
Monitor clinical response and sedation or anticholinergic effects, and adjust the doxepin dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Peginterferon alfa 2b
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Doxepin and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa-2b may modestly alter CYP2D6 activity, potentially changing doxepin exposure. Interferons also commonly cause depression and insomnia, so doxepin response should be followed.
How serious is the interaction between Doxepin and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and sedation or anticholinergic effects, and adjust the doxepin dose as needed.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
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