Drug interactions
Doxepin + Succinylcholine
Severity: Minor
Doxepin and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin has anticholinergic properties, but these do not meaningfully change the neuromuscular action of succinylcholine. Tricyclic antidepressants may add to arrhythmia risk when combined with agents that cause autonomic or electrolyte changes in anesthesia.
What this interaction means in plain words
Doxepin and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Succinylcholine belongs to Musculoskeletal.
Why it happens
Anticholinergic and sodium-channel-blocking effects of doxepin may add to arrhythmia risk; there is no established effect on blockade.
What to do
Monitor ECG and heart rate during anesthesia in patients taking doxepin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Succinylcholine
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Succinylcholine?
MediHelp rates the interaction as minor. Doxepin and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxepin has anticholinergic properties, but these do not meaningfully change the neuromuscular action of succinylcholine. Tricyclic antidepressants may add to arrhythmia risk when combined with agents that cause autonomic or electrolyte changes in anesthesia.
How serious is the interaction between Doxepin and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate during anesthesia in patients taking doxepin.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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