Drug interactions
Doxepin + Zolmitriptan
Severity: Moderate
Doxepin and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin inhibits serotonin reuptake, and with zolmitriptan it may rarely cause serotonin syndrome. Low-dose doxepin for insomnia carries a smaller risk.
What this interaction means in plain words
Doxepin and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Zolmitriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic activity via reuptake inhibition and 5-HT1 agonism.
What to do
Educate on serotonin syndrome symptoms and monitor after dose changes. Discontinue the agents and give supportive care if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Zolmitriptan?
MediHelp rates the interaction as moderate. Doxepin and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin inhibits serotonin reuptake, and with zolmitriptan it may rarely cause serotonin syndrome. Low-dose doxepin for insomnia carries a smaller risk.
How serious is the interaction between Doxepin and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Educate on serotonin syndrome symptoms and monitor after dose changes. Discontinue the agents and give supportive care if it occurs.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
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