Drug interactions
Doxorubicin + Elagolix
Severity: Moderate
Doxorubicin and Elagolix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a P-gp inhibitor and a weak-to-moderate CYP3A4 inducer, so effects on doxorubicin may go in opposite directions. The net clinical effect is uncertain.
What this interaction means in plain words
Doxorubicin and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Elagolix belongs to Musculoskeletal.
Why it happens
Elagolix inhibits P-gp and induces CYP3A4, with an uncertain net effect on doxorubicin exposure.
What to do
Monitor for doxorubicin toxicity and for reduced efficacy. Consider an alternative to elagolix if the patient is being treated with chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Doxorubicin with Elagolix?
MediHelp rates the interaction as moderate. Doxorubicin and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a P-gp inhibitor and a weak-to-moderate CYP3A4 inducer, so effects on doxorubicin may go in opposite directions. The net clinical effect is uncertain.
How serious is the interaction between Doxorubicin and Elagolix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for doxorubicin toxicity and for reduced efficacy. Consider an alternative to elagolix if the patient is being treated with chemotherapy.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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