Drug interactions
Doxorubicin + Enzalutamide
Severity: Minor
Doxorubicin and Enzalutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is cleared mainly by carbonyl reductases, biliary excretion and P-gp, with only minor CYP3A4 involvement. A clinically significant effect of enzalutamide is not expected.
What this interaction means in plain words
Doxorubicin and Enzalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Enzalutamide belongs to Endocrine.
Why it happens
Possible minor increase in clearance through enzyme and transporter induction; the clinical relevance is not established.
What to do
No dose adjustment is needed; monitor response and toxicity as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Enzalutamide?
MediHelp rates the interaction as minor. Doxorubicin and Enzalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin is cleared mainly by carbonyl reductases, biliary excretion and P-gp, with only minor CYP3A4 involvement. A clinically significant effect of enzalutamide is not expected.
How serious is the interaction between Doxorubicin and Enzalutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor response and toxicity as usual.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
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