Drug interactions
Doxorubicin + Tucatinib
Severity: Moderate
Doxorubicin and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may raise doxorubicin exposure, though doxorubicin is cleared mainly by other pathways including carbonyl reductase and P-gp. Higher exposure could worsen myelosuppression and cardiotoxicity.
What this interaction means in plain words
Doxorubicin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4 and P-glycoprotein, potentially reducing doxorubicin clearance.
What to do
Monitor blood counts and cardiac status closely and consider doxorubicin dose reduction if toxicity develops. Prefer an alternative where practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Doxorubicin with Tucatinib?
MediHelp rates the interaction as moderate. Doxorubicin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and may raise doxorubicin exposure, though doxorubicin is cleared mainly by other pathways including carbonyl reductase and P-gp. Higher exposure could worsen myelosuppression and cardiotoxicity.
How serious is the interaction between Doxorubicin and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac status closely and consider doxorubicin dose reduction if toxicity develops. Prefer an alternative where practical.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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