Drug interactions
Doxycycline + Eliglustat
Severity: Minor
Doxycycline and Eliglustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is metabolized by CYP2D6 and CYP3A4, and inhibitors raise its exposure with a risk of QT prolongation. Doxycycline is only a weak, poorly documented CYP3A4 inhibitor, so any effect is likely small.
What this interaction means in plain words
Doxycycline and Eliglustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Eliglustat belongs to Miscellaneous.
Why it happens
Possible weak CYP3A4 inhibition may slightly raise eliglustat exposure; not established for doxycycline.
What to do
No dose change is routinely needed; consider an ECG if the patient is a CYP2D6 poor metabolizer or has other QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Doxycycline with Eliglustat?
MediHelp rates the interaction as minor. Doxycycline and Eliglustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat is metabolized by CYP2D6 and CYP3A4, and inhibitors raise its exposure with a risk of QT prolongation. Doxycycline is only a weak, poorly documented CYP3A4 inhibitor, so any effect is likely small.
How serious is the interaction between Doxycycline and Eliglustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; consider an ECG if the patient is a CYP2D6 poor metabolizer or has other QT risk factors.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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