Drug interactions
Doxycycline + Sonidegib
Severity: Minor
Doxycycline and Sonidegib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sonidegib is a CYP3A4 substrate, and moderate CYP3A4 inhibitors can raise its levels and the risk of musculoskeletal toxicity such as CK elevation and myopathy. Doxycycline is not a recognized clinically relevant CYP3A4 inhibitor, so the risk is largely theoretical.
What this interaction means in plain words
Doxycycline and Sonidegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Sonidegib belongs to Oncology.
Why it happens
Theoretical CYP3A4 inhibition by doxycycline decreasing sonidegib clearance; not well established.
What to do
Monitor for muscle pain, weakness and CK elevation during combined use; no empirical dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Doxycycline with Sonidegib?
MediHelp rates the interaction as minor. Doxycycline and Sonidegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sonidegib is a CYP3A4 substrate, and moderate CYP3A4 inhibitors can raise its levels and the risk of musculoskeletal toxicity such as CK elevation and myopathy. Doxycycline is not a recognized clinically relevant CYP3A4 inhibitor, so the risk is largely theoretical.
How serious is the interaction between Doxycycline and Sonidegib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and CK elevation during combined use; no empirical dose change is needed.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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