Drug interactions
Doxycycline + Tazemetostat
Severity: Minor
Doxycycline and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is metabolized by CYP3A4, so inhibitors can raise its exposure and adverse effects. Doxycycline is not a recognized CYP3A4 inhibitor, so a clinically meaningful change is unlikely.
What this interaction means in plain words
Doxycycline and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Tazemetostat belongs to Miscellaneous.
Why it happens
Theoretical weak CYP3A4 inhibition by doxycycline.
What to do
No empiric dose change; monitor for tazemetostat adverse effects and blood counts as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Doxycycline with Tazemetostat?
MediHelp rates the interaction as minor. Doxycycline and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is metabolized by CYP3A4, so inhibitors can raise its exposure and adverse effects. Doxycycline is not a recognized CYP3A4 inhibitor, so a clinically meaningful change is unlikely.
How serious is the interaction between Doxycycline and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change; monitor for tazemetostat adverse effects and blood counts as routine.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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