Drug interactions
Doxylamine + Mirtazapine
Severity: Moderate
Doxylamine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating antihistamine often used for sleep, and with mirtazapine can produce excessive drowsiness and impaired next-day performance. Anticholinergic effects may also add to confusion in older adults.
What this interaction means in plain words
Doxylamine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive H1 receptor antagonism and CNS depression.
What to do
Avoid combining for sleep; use one agent at the lowest effective dose. Counsel about driving and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Mirtazapine?
MediHelp rates the interaction as moderate. Doxylamine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating antihistamine often used for sleep, and with mirtazapine can produce excessive drowsiness and impaired next-day performance. Anticholinergic effects may also add to confusion in older adults.
How serious is the interaction between Doxylamine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining for sleep; use one agent at the lowest effective dose. Counsel about driving and avoid alcohol.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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