Drug interactions
Doxylamine + Pregabalin
Severity: Moderate
Doxylamine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating antihistamine, and combining it with pregabalin can intensify drowsiness, dizziness and cognitive impairment. Respiratory depression is a concern in frail patients or those with respiratory disease.
What this interaction means in plain words
Doxylamine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depression from pregabalin and doxylamine.
What to do
Use the lowest effective doses and avoid nighttime doxylamine in elderly patients on pregabalin where possible. Monitor for oversedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Pregabalin?
MediHelp rates the interaction as moderate. Doxylamine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating antihistamine, and combining it with pregabalin can intensify drowsiness, dizziness and cognitive impairment. Respiratory depression is a concern in frail patients or those with respiratory disease.
How serious is the interaction between Doxylamine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid nighttime doxylamine in elderly patients on pregabalin where possible. Monitor for oversedation and respiratory depression.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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