Drug interactions
Doxylamine + Tramadol
Severity: Moderate
Doxylamine and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating antihistamine, and its effects add to opioid drowsiness and impaired alertness. Older patients are particularly prone to confusion and falls.
What this interaction means in plain words
Doxylamine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression via H1 antagonism and opioid agonism.
What to do
Monitor for oversedation and avoid driving; use a non-sedating alternative where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Tramadol?
MediHelp rates the interaction as moderate. Doxylamine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating antihistamine, and its effects add to opioid drowsiness and impaired alertness. Older patients are particularly prone to confusion and falls.
How serious is the interaction between Doxylamine and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and avoid driving; use a non-sedating alternative where possible.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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