Drug interactions
Doxylamine + Trimipramine
Severity: Moderate
Doxylamine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating, anticholinergic antihistamine, so taking it with trimipramine increases drowsiness and impairs alertness. Anticholinergic effects such as dry mouth, constipation and urinary retention may also be amplified.
What this interaction means in plain words
Doxylamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive H1 antagonism and antimuscarinic effects.
What to do
Avoid using doxylamine as a sleep aid with trimipramine where possible. Counsel on driving and monitor for excessive sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Trimipramine?
MediHelp rates the interaction as moderate. Doxylamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating, anticholinergic antihistamine, so taking it with trimipramine increases drowsiness and impairs alertness. Anticholinergic effects such as dry mouth, constipation and urinary retention may also be amplified.
How serious is the interaction between Doxylamine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using doxylamine as a sleep aid with trimipramine where possible. Counsel on driving and monitor for excessive sedation and anticholinergic effects.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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