Drug interactions
Dronabinol + Nicardipine
Severity: Moderate
Dronabinol and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronabinol is metabolized by CYP2C9 and CYP3A4, both of which nicardipine can inhibit in vitro. Exposure to dronabinol may rise, increasing tachycardia, dizziness, sedation and cognitive effects.
What this interaction means in plain words
Dronabinol and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronabinol belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Nicardipine inhibits CYP2C9 and CYP3A4 metabolism of dronabinol.
What to do
Monitor for increased psychoactive and cardiovascular effects. Reduce dronabinol dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dronabinol and Nicardipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nicardipine
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Nicardipine?
MediHelp rates the interaction as moderate. Dronabinol and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronabinol is metabolized by CYP2C9 and CYP3A4, both of which nicardipine can inhibit in vitro. Exposure to dronabinol may rise, increasing tachycardia, dizziness, sedation and cognitive effects.
How serious is the interaction between Dronabinol and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased psychoactive and cardiovascular effects. Reduce dronabinol dose if adverse effects develop.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
