Drug interactions
Dronabinol + Secobarbital
Severity: Moderate
Dronabinol and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may induce enzymes that metabolise dronabinol, potentially lowering its concentrations and weakening its effect on appetite or nausea. Both agents also cause CNS depression, so sedation and impaired cognition may be increased.
What this interaction means in plain words
Dronabinol and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronabinol belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
CYP2C9 and CYP3A4 induction by secobarbital increases dronabinol metabolism, together with additive CNS depression.
What to do
Monitor for reduced dronabinol effect and titrate its dose as needed. Warn the patient about additive drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Secobarbital?
MediHelp rates the interaction as moderate. Dronabinol and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may induce enzymes that metabolise dronabinol, potentially lowering its concentrations and weakening its effect on appetite or nausea. Both agents also cause CNS depression, so sedation and impaired cognition may be increased.
How serious is the interaction between Dronabinol and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced dronabinol effect and titrate its dose as needed. Warn the patient about additive drowsiness.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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