Drug interactions
Dronedarone + Dutasteride-tamsulosin
Severity: Major
Dronedarone and Dutasteride-tamsulosin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits both CYP3A4 and CYP2D6, so it can increase tamsulosin exposure. It also lowers blood pressure and heart rate, raising the risk of hypotension and dizziness.
What this interaction means in plain words
Dronedarone and Dutasteride-tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Dronedarone inhibits CYP3A4 and CYP2D6, reducing tamsulosin clearance.
What to do
Monitor blood pressure and orthostatic symptoms closely and reduce the tamsulosin dose if symptoms occur. Consider an alternative if hypotension is troublesome.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Dutasteride-tamsulosin?
MediHelp rates the interaction as major. Dronedarone and Dutasteride-tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone inhibits both CYP3A4 and CYP2D6, so it can increase tamsulosin exposure. It also lowers blood pressure and heart rate, raising the risk of hypotension and dizziness.
How serious is the interaction between Dronedarone and Dutasteride-tamsulosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms closely and reduce the tamsulosin dose if symptoms occur. Consider an alternative if hypotension is troublesome.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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