Drug interactions
Dronedarone + Duvelisib
Severity: Major
Dronedarone and Duvelisib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can raise dronedarone concentrations, which may increase QT prolongation, bradycardia and other adverse effects. Dronedarone may in turn raise duvelisib levels through P-glycoprotein inhibition.
What this interaction means in plain words
Dronedarone and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Duvelisib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, reducing dronedarone clearance, and dronedarone inhibits P-glycoprotein, which may increase duvelisib absorption.
What to do
Avoid the combination where possible, or monitor ECG and heart rate closely. Watch for duvelisib toxicities such as infection, diarrhea and rash.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Dronedarone 400 mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: substrates of P-glycoproteins, CYP 3A4 or CYP 2D6; "Dronedarone has therefore, the potential to interact on medicinal products substrates of P-glycoproteins, CYP 3A4 or CYP 2D6.") — electronic medicines compendium (UK SmPC)
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Dronedarone with Duvelisib?
MediHelp rates the interaction as major. Dronedarone and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib inhibits CYP3A4 and can raise dronedarone concentrations, which may increase QT prolongation, bradycardia and other adverse effects. Dronedarone may in turn raise duvelisib levels through P-glycoprotein inhibition.
How serious is the interaction between Dronedarone and Duvelisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor ECG and heart rate closely. Watch for duvelisib toxicities such as infection, diarrhea and rash.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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