Drug interactions
Dronedarone + Elacestrant
Severity: Moderate
Dronedarone and Elacestrant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone, a moderate CYP3A4 inhibitor, may increase elacestrant exposure. This may increase its adverse effects such as nausea and dyslipidemia.
What this interaction means in plain words
Dronedarone and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Elacestrant belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism of elacestrant.
What to do
Monitor for increased adverse effects of elacestrant. Consider an alternative to dronedarone if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Dronedarone with Elacestrant?
MediHelp rates the interaction as moderate. Dronedarone and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone, a moderate CYP3A4 inhibitor, may increase elacestrant exposure. This may increase its adverse effects such as nausea and dyslipidemia.
How serious is the interaction between Dronedarone and Elacestrant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased adverse effects of elacestrant. Consider an alternative to dronedarone if tolerability is poor.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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