Drug interactions
Dronedarone + Fluoxetine
Severity: Major
Dronedarone and Fluoxetine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and fluoxetine also inhibits CYP2D6 and may modestly raise dronedarone exposure. Together they increase the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Dronedarone and Fluoxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible CYP-mediated increase in dronedarone levels.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes, correcting potassium and magnesium. Consider an alternative antidepressant with lower QT risk, such as sertraline, if QTc lengthens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Dronedarone with Fluoxetine?
MediHelp rates the interaction as major. Dronedarone and Fluoxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and fluoxetine also inhibits CYP2D6 and may modestly raise dronedarone exposure. Together they increase the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Dronedarone and Fluoxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes, correcting potassium and magnesium. Consider an alternative antidepressant with lower QT risk, such as sertraline, if QTc lengthens.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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