Drug interactions
Dronedarone + Fluticasone-vilanterol
Severity: Major
Dronedarone and Fluticasone-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone prolongs the QT interval and vilanterol may add to proarrhythmic risk. Dronedarone is also a moderate CYP3A4 inhibitor which may modestly raise fluticasone furoate and vilanterol exposure.
What this interaction means in plain words
Dronedarone and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QTc prolongation plus CYP3A4 inhibition by dronedarone increasing inhaled drug exposure.
What to do
Obtain a baseline ECG and monitor QTc, heart rate and potassium during combined use. Consider a different bronchodilator regimen if QT prolongation or palpitations develop.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Dronedarone and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone prolongs the QT interval and vilanterol may add to proarrhythmic risk. Dronedarone is also a moderate CYP3A4 inhibitor which may modestly raise fluticasone furoate and vilanterol exposure.
How serious is the interaction between Dronedarone and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, heart rate and potassium during combined use. Consider a different bronchodilator regimen if QT prolongation or palpitations develop.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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