Drug interactions
Dronedarone + Fostemsavir
Severity: Moderate
Dronedarone and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir has caused QTc prolongation at supratherapeutic doses, and dronedarone prolongs QT by itself. Together they may increase the risk of torsades de pointes, especially with other risk factors.
What this interaction means in plain words
Dronedarone and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Fostemsavir belongs to Anti Virals.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG at baseline and during therapy, and correct hypokalemia and hypomagnesemia. Avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Dronedarone with Fostemsavir?
MediHelp rates the interaction as moderate. Dronedarone and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir has caused QTc prolongation at supratherapeutic doses, and dronedarone prolongs QT by itself. Together they may increase the risk of torsades de pointes, especially with other risk factors.
How serious is the interaction between Dronedarone and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG at baseline and during therapy, and correct hypokalemia and hypomagnesemia. Avoid adding further QT-prolonging drugs.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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