Drug interactions
Dronedarone + Guanfacine
Severity: Moderate
Dronedarone and Guanfacine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and can raise guanfacine blood levels. Higher exposure may cause excessive lowering of blood pressure, bradycardia and sedation, which is additive with dronedarone's own effects on heart rate.
What this interaction means in plain words
Dronedarone and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Guanfacine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated metabolism of guanfacine by dronedarone.
What to do
With extended-release guanfacine, reduce the dose to half of the usual recommended dose, as labeled for CYP3A4 inhibitors. Monitor heart rate, blood pressure and sedation, and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dronedarone and Guanfacine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Dronedarone with Guanfacine?
MediHelp rates the interaction as moderate. Dronedarone and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone is a moderate CYP3A4 inhibitor and can raise guanfacine blood levels. Higher exposure may cause excessive lowering of blood pressure, bradycardia and sedation, which is additive with dronedarone's own effects on heart rate.
How serious is the interaction between Dronedarone and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With extended-release guanfacine, reduce the dose to half of the usual recommended dose, as labeled for CYP3A4 inhibitors. Monitor heart rate, blood pressure and sedation, and adjust the dose accordingly.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
