Drug interactions
Dronedarone + Imatinib
Severity: Moderate
Dronedarone and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a substrate of P-glycoprotein and CYP3A4, and it also inhibits CYP3A4 itself. Dronedarone may raise imatinib levels, increasing fluid retention, myelosuppression and gastrointestinal effects, and both drugs can affect QT.
What this interaction means in plain words
Dronedarone and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Imatinib belongs to Oncology.
Why it happens
Dronedarone inhibition of P-glycoprotein and CYP3A4 reduces imatinib clearance, with possible additive QT effects.
What to do
Monitor for imatinib toxicity and blood counts, and obtain an ECG if there are other QT risk factors. Reduce the imatinib dose if adverse effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Dronedarone with Imatinib?
MediHelp rates the interaction as moderate. Dronedarone and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib is a substrate of P-glycoprotein and CYP3A4, and it also inhibits CYP3A4 itself. Dronedarone may raise imatinib levels, increasing fluid retention, myelosuppression and gastrointestinal effects, and both drugs can affect QT.
How serious is the interaction between Dronedarone and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib toxicity and blood counts, and obtain an ECG if there are other QT risk factors. Reduce the imatinib dose if adverse effects arise.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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