Drug interactions
Dronedarone + Isavuconazonium
Severity: Moderate
Dronedarone and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate, and dronedarone as a moderate inhibitor may increase its levels. Isavuconazole itself is a moderate CYP3A4 inhibitor and shortens the QT interval, but may increase dronedarone exposure.
What this interaction means in plain words
Dronedarone and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Isavuconazonium belongs to Anti Fungals.
Why it happens
Bidirectional CYP3A4 inhibition, with dronedarone raising isavuconazole levels.
What to do
Monitor for isavuconazole adverse effects including hepatic effects, and monitor heart rate and ECG for dronedarone toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Dronedarone with Isavuconazonium?
MediHelp rates the interaction as moderate. Dronedarone and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a CYP3A4 substrate, and dronedarone as a moderate inhibitor may increase its levels. Isavuconazole itself is a moderate CYP3A4 inhibitor and shortens the QT interval, but may increase dronedarone exposure.
How serious is the interaction between Dronedarone and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for isavuconazole adverse effects including hepatic effects, and monitor heart rate and ECG for dronedarone toxicity.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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