Drug interactions
Dronedarone + Lemborexant
Severity: Major
Dronedarone and Lemborexant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may raise lemborexant concentrations, leading to greater somnolence, next-day impairment and complex sleep behaviors. Moderate CYP3A inhibitors are known to increase lemborexant exposure.
What this interaction means in plain words
Dronedarone and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Lemborexant belongs to Central Nervous System.
Why it happens
Dronedarone inhibits CYP3A4, reducing lemborexant clearance.
What to do
Avoid the combination if possible. If used, keep lemborexant at the lowest labeled dose and monitor for excessive sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Dronedarone with Lemborexant?
MediHelp rates the interaction as major. Dronedarone and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone may raise lemborexant concentrations, leading to greater somnolence, next-day impairment and complex sleep behaviors. Moderate CYP3A inhibitors are known to increase lemborexant exposure.
How serious is the interaction between Dronedarone and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, keep lemborexant at the lowest labeled dose and monitor for excessive sedation.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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