Drug interactions
Dronedarone + Lurbinectedin
Severity: Major
Dronedarone and Lurbinectedin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may increase lurbinectedin exposure, raising the risk of myelosuppression and hepatotoxicity. Lurbinectedin is mainly cleared by CYP3A4.
What this interaction means in plain words
Dronedarone and Lurbinectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Lurbinectedin belongs to Oncology.
Why it happens
Dronedarone inhibits CYP3A4, decreasing lurbinectedin metabolism.
What to do
Avoid the combination if possible. If required, consider lurbinectedin dose reduction per labeling and monitor blood counts and liver tests.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Dronedarone with Lurbinectedin?
MediHelp rates the interaction as major. Dronedarone and Lurbinectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone may increase lurbinectedin exposure, raising the risk of myelosuppression and hepatotoxicity. Lurbinectedin is mainly cleared by CYP3A4.
How serious is the interaction between Dronedarone and Lurbinectedin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If required, consider lurbinectedin dose reduction per labeling and monitor blood counts and liver tests.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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