Drug interactions
Dronedarone + Naloxegol
Severity: Moderate
Dronedarone and Naloxegol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone can raise naloxegol concentrations, increasing the risk of opioid withdrawal-like symptoms and gastrointestinal effects such as abdominal pain and diarrhea. Naloxegol is a CYP3A4 and P-glycoprotein substrate.
What this interaction means in plain words
Dronedarone and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Dronedarone inhibits CYP3A4 and P-glycoprotein, reducing naloxegol clearance.
What to do
If coadministration is needed, use the reduced naloxegol dose of 12.5 mg daily and monitor for withdrawal symptoms and abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dronedarone and Naloxegol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Dronedarone with Naloxegol?
MediHelp rates the interaction as moderate. Dronedarone and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone can raise naloxegol concentrations, increasing the risk of opioid withdrawal-like symptoms and gastrointestinal effects such as abdominal pain and diarrhea. Naloxegol is a CYP3A4 and P-glycoprotein substrate.
How serious is the interaction between Dronedarone and Naloxegol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration is needed, use the reduced naloxegol dose of 12.5 mg daily and monitor for withdrawal symptoms and abdominal pain.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
