Drug interactions
Dronedarone + Nebivolol
Severity: Major
Dronedarone and Nebivolol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP2D6 and may increase nebivolol exposure. It also has its own bradycardic and AV-nodal effects, so the combination raises the risk of bradycardia and conduction block.
What this interaction means in plain words
Dronedarone and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6 metabolism of nebivolol plus additive negative chronotropic and dromotropic effects.
What to do
Start nebivolol at a low dose and monitor ECG and heart rate. Reduce the dose if bradycardia or AV block develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Nebivolol?
MediHelp rates the interaction as major. Dronedarone and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone inhibits CYP2D6 and may increase nebivolol exposure. It also has its own bradycardic and AV-nodal effects, so the combination raises the risk of bradycardia and conduction block.
How serious is the interaction between Dronedarone and Nebivolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start nebivolol at a low dose and monitor ECG and heart rate. Reduce the dose if bradycardia or AV block develops.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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