Drug interactions
Dronedarone + Nicardipine
Severity: Moderate
Dronedarone and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and can increase nicardipine exposure, causing hypotension, edema and dizziness. Dronedarone itself also has negative chronotropic effects that may add to calcium channel blocker effects.
What this interaction means in plain words
Dronedarone and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP3A4-mediated metabolism of nicardipine.
What to do
Start nicardipine at a low dose and monitor blood pressure and heart rate. Adjust dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Nicardipine?
MediHelp rates the interaction as moderate. Dronedarone and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone is a moderate CYP3A4 inhibitor and can increase nicardipine exposure, causing hypotension, edema and dizziness. Dronedarone itself also has negative chronotropic effects that may add to calcium channel blocker effects.
How serious is the interaction between Dronedarone and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start nicardipine at a low dose and monitor blood pressure and heart rate. Adjust dose to response.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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