Drug interactions
Dronedarone + Oliceridine
Severity: Moderate
Dronedarone and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits both CYP3A4 and CYP2D6, the main pathways for oliceridine metabolism, and may raise opioid levels. This increases the risk of respiratory depression and sedation.
What this interaction means in plain words
Dronedarone and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Oliceridine belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4 and CYP2D6 metabolism of oliceridine.
What to do
Monitor for respiratory depression and sedation and use less frequent or lower oliceridine doses as needed. If dronedarone is stopped, watch for reduced analgesia and withdrawal and adjust the dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Dronedarone with Oliceridine?
MediHelp rates the interaction as moderate. Dronedarone and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits both CYP3A4 and CYP2D6, the main pathways for oliceridine metabolism, and may raise opioid levels. This increases the risk of respiratory depression and sedation.
How serious is the interaction between Dronedarone and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for respiratory depression and sedation and use less frequent or lower oliceridine doses as needed. If dronedarone is stopped, watch for reduced analgesia and withdrawal and adjust the dose.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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