Drug interactions
Dronedarone + Oxymorphone
Severity: Minor
Dronedarone and Oxymorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP2D6, but oxymorphone is metabolized mainly by glucuronidation, so a clinically meaningful rise in exposure is unlikely. The interaction is largely theoretical.
What this interaction means in plain words
Dronedarone and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Oxymorphone belongs to Musculoskeletal.
Why it happens
Dronedarone inhibits CYP2D6, which is a minor route for oxymorphone.
What to do
No dose adjustment is generally needed; observe for increased opioid effects when starting dronedarone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Oxymorphone?
MediHelp rates the interaction as minor. Dronedarone and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone inhibits CYP2D6, but oxymorphone is metabolized mainly by glucuronidation, so a clinically meaningful rise in exposure is unlikely. The interaction is largely theoretical.
How serious is the interaction between Dronedarone and Oxymorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; observe for increased opioid effects when starting dronedarone.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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