Drug interactions
Dronedarone + Paclitaxel
Severity: Moderate
Dronedarone and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is a P-glycoprotein substrate and is metabolized by CYP2C8 and CYP3A4. Dronedarone may raise paclitaxel exposure, increasing neutropenia and neuropathy.
What this interaction means in plain words
Dronedarone and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Paclitaxel belongs to Oncology.
Why it happens
Dronedarone inhibits P-glycoprotein and CYP3A4, reducing paclitaxel elimination.
What to do
Monitor blood counts and neuropathy, and reduce the paclitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Paclitaxel
Frequently asked questions
Can I take Dronedarone with Paclitaxel?
MediHelp rates the interaction as moderate. Dronedarone and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel is a P-glycoprotein substrate and is metabolized by CYP2C8 and CYP3A4. Dronedarone may raise paclitaxel exposure, increasing neutropenia and neuropathy.
How serious is the interaction between Dronedarone and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy, and reduce the paclitaxel dose if toxicity develops.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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