Drug interactions
Dronedarone + Pexidartinib
Severity: Major
Dronedarone and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may increase pexidartinib exposure, raising the risk of hepatotoxicity, which can be serious. Pexidartinib is a CYP3A4 substrate.
What this interaction means in plain words
Dronedarone and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Pexidartinib belongs to Oncology.
Why it happens
Dronedarone inhibits CYP3A4, decreasing pexidartinib clearance.
What to do
Avoid if possible. If required, reduce the pexidartinib dose per labeling and monitor liver tests closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Dronedarone with Pexidartinib?
MediHelp rates the interaction as major. Dronedarone and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone may increase pexidartinib exposure, raising the risk of hepatotoxicity, which can be serious. Pexidartinib is a CYP3A4 substrate.
How serious is the interaction between Dronedarone and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If required, reduce the pexidartinib dose per labeling and monitor liver tests closely.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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