Drug interactions
Dronedarone + Quetiapine
Severity: Major
Dronedarone and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP3A4, the main route of quetiapine clearance, raising quetiapine levels with more sedation and hypotension. Both drugs also prolong QT, increasing torsades risk.
What this interaction means in plain words
Dronedarone and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Quetiapine belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by dronedarone raises quetiapine exposure, with additive QT prolongation.
What to do
Avoid if possible; otherwise consider reducing the quetiapine dose and monitor ECG and electrolytes. Choose an antipsychotic with lower QT risk when feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Dronedarone with Quetiapine?
MediHelp rates the interaction as major. Dronedarone and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone inhibits CYP3A4, the main route of quetiapine clearance, raising quetiapine levels with more sedation and hypotension. Both drugs also prolong QT, increasing torsades risk.
How serious is the interaction between Dronedarone and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise consider reducing the quetiapine dose and monitor ECG and electrolytes. Choose an antipsychotic with lower QT risk when feasible.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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