Drug interactions
Dronedarone + Riociguat
Severity: Moderate
Dronedarone and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A inhibitor and may raise riociguat exposure. Greater exposure can cause symptomatic hypotension, dizziness and syncope.
What this interaction means in plain words
Dronedarone and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 metabolism of riociguat leads to higher plasma levels.
What to do
Monitor blood pressure and consider a lower riociguat starting dose with slow titration. Reduce the dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Dronedarone with Riociguat?
MediHelp rates the interaction as moderate. Dronedarone and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone is a moderate CYP3A inhibitor and may raise riociguat exposure. Greater exposure can cause symptomatic hypotension, dizziness and syncope.
How serious is the interaction between Dronedarone and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and consider a lower riociguat starting dose with slow titration. Reduce the dose if hypotension develops.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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