Drug interactions
Dronedarone + Sufentanil
Severity: Moderate
Dronedarone and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is cleared through CYP3A4, and dronedarone as a moderate inhibitor may increase its exposure. This can prolong or intensify opioid effects such as respiratory depression and sedation, and bradycardia may be additive.
What this interaction means in plain words
Dronedarone and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Sufentanil belongs to Musculoskeletal.
Why it happens
Dronedarone inhibits CYP3A4 metabolism of sufentanil.
What to do
Monitor respiratory status, sedation and heart rate, and use the lowest effective sufentanil dose. Be prepared to adjust dosing, especially with prolonged infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dronedarone and Sufentanil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Dronedarone with Sufentanil?
MediHelp rates the interaction as moderate. Dronedarone and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is cleared through CYP3A4, and dronedarone as a moderate inhibitor may increase its exposure. This can prolong or intensify opioid effects such as respiratory depression and sedation, and bradycardia may be additive.
How serious is the interaction between Dronedarone and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status, sedation and heart rate, and use the lowest effective sufentanil dose. Be prepared to adjust dosing, especially with prolonged infusion.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
