Drug interactions
Dronedarone + Tamsulosin
Severity: Moderate
Dronedarone and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits both CYP3A4 and CYP2D6, the two main enzymes that clear tamsulosin, so tamsulosin exposure may rise noticeably. This can intensify alpha-blocker effects such as orthostatic hypotension, dizziness and syncope.
What this interaction means in plain words
Dronedarone and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Tamsulosin belongs to Genitourinary.
Why it happens
Dronedarone inhibits CYP3A4 and CYP2D6, reducing the metabolic clearance of tamsulosin.
What to do
Monitor blood pressure and orthostatic symptoms, particularly when starting dronedarone or after dose changes. Consider a lower tamsulosin dose or an alternative if dizziness or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Tamsulosin?
MediHelp rates the interaction as moderate. Dronedarone and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits both CYP3A4 and CYP2D6, the two main enzymes that clear tamsulosin, so tamsulosin exposure may rise noticeably. This can intensify alpha-blocker effects such as orthostatic hypotension, dizziness and syncope.
How serious is the interaction between Dronedarone and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly when starting dronedarone or after dose changes. Consider a lower tamsulosin dose or an alternative if dizziness or hypotension develops.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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