Drug interactions
Dronedarone + Tinidazole
Severity: Moderate
Dronedarone and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and may raise tinidazole concentrations. Both drugs can prolong the QT interval or cause gastrointestinal effects, so combined use may increase the risk of adverse reactions.
What this interaction means in plain words
Dronedarone and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Tinidazole belongs to Anti Parasitic.
Why it happens
Dronedarone inhibits CYP3A4, reducing tinidazole clearance, with possible additive QT effects.
What to do
Obtain a baseline ECG and monitor QT interval and electrolytes if the combination is needed; consider an alternative antimicrobial where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Tinidazole?
MediHelp rates the interaction as moderate. Dronedarone and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone is a moderate CYP3A4 inhibitor and may raise tinidazole concentrations. Both drugs can prolong the QT interval or cause gastrointestinal effects, so combined use may increase the risk of adverse reactions.
How serious is the interaction between Dronedarone and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QT interval and electrolytes if the combination is needed; consider an alternative antimicrobial where possible.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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