Drug interactions
Dronedarone + Vinblastine
Severity: Moderate
Dronedarone and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may raise vinblastine exposure by reducing its cellular efflux. This could increase myelosuppression and neurotoxicity.
What this interaction means in plain words
Dronedarone and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Vinblastine belongs to Oncology.
Why it happens
Dronedarone inhibits P-glycoprotein, reducing vinblastine efflux and elimination.
What to do
Monitor blood counts and for neurotoxicity during co-therapy. Reduce the vinblastine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Vinblastine
Frequently asked questions
Can I take Dronedarone with Vinblastine?
MediHelp rates the interaction as moderate. Dronedarone and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may raise vinblastine exposure by reducing its cellular efflux. This could increase myelosuppression and neurotoxicity.
How serious is the interaction between Dronedarone and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neurotoxicity during co-therapy. Reduce the vinblastine dose if toxicity develops.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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